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10 GENERAL PROBLEMS OF (AND PERSPECTIVES FOR) FMRI OF MOTOR FUNCTION

10 GENERAL PROBLEMS OF (AND PERSPECTIVES FOR) FMRI OF MOTOR FUNCTION

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motor control in particular. Sensorimotor function is associated with a distributed

neural substrate, and the fact that fMRI readily covers the entire brain is helpful in

this respect. Highly focalized research techniques are hypothesis-driven, at least in

terms of the location they target, and this impairs the potential for new discoveries.

In that sense, even if fuzzy, a picture of activity in the entire brain may help to

generate and then test novel hypotheses, apart from offering plausibility controls for

ongoing studies. Furthermore, the fact that the contrast agent exploited in the BOLD

contrast is endogenous and thus permanently present permits a true neurophysiological recording that can go beyond evoked responses.

However, the spatiotemporal response function, i.e., the dispersion of the fMRI

response in time and space, poses the most relevant limitation for this type of

recording. In other words, fMRI hits hard biological limits, not technical ones, even

though technical difficulties are abundant and not yet always fully mastered. Studies

in the visual system with fMRI have established that dedicated acquisition and

analysis techniques can resolve much smaller functional cortical units than in the

currently available motor studies discussed here.166 This increase in spatial resolution

is of interest because, in contrast to earlier neuroimaging techniques, fMRI experiments readily generate highly significant findings in single subjects.

Many of the topics discussed in the previous sections illustrated that one of the

major shortcomings of functional neuroimaging studies still lies in the uncertainties

of anatomical labeling. Each brain is different, but previous neuroimaging techniques

required normalizing the data into a common standard stereotactic space so as to

perform averaging of voxel-based signals from roughly homologous brain areas

across subjects. These group analyses then had sufficient statistical power and the

advantage of ensuring some degree of generality in terms of volume coverage and

intersubject variability. Yet, the price paid for this procedure was at the level of

anatomical analysis. Even if a spatial normalizing technique incorporates nonlinear

algorithms that warp one gyrification pattern rather well into another, the correspondence of actual brain areas becomes blurred by these procedures, and accordingly

probabilistic atlases are the closest one can get to reality in this setting. In the

previous sections, it has become obvious that such maps can indeed be helpful in

tentatively assigning fMRI responses to certain areas, but often enough, even probabilistic statements leave painful uncertainties as to which areas we are obtaining

effects from.

But what defines an area as charted in an atlas? The set of neuroanatomical

criteria range from cyto- and myeloarchitectonic features to densities and laminar

distributions of receptors and other neurochemical markers.167 In the case of M1,

recent detailed analyses have demonstrated a considerable degree of variability both

between different brains and within individual brains, i.e., between hemispheres.168

Moreover, similar methods have rather recently unveiled the fact that, regarding

Brodmann area 4, we are actually dealing with two architectonically distinct areas

instead of one.169 If form follows function, we must also assume different response

properties of these two areas, and we have discussed some of the evidence from

functional neuroimaging that this may indeed be the case. However, these conclusions were based on relating functional findings from one or several brains to a

database formed from many other and thus different brains. The desideratum at this



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stage is to map areas in individual subjects, namely those subjects in whom we can

also obtain physiological observations, thus avoiding the limitations introduced by

intersubject variability. Whether this will be achieved by morphological or functional

criteria is not yet clear, but in any case this will need to be done in a noninvasive

fashion and will thus require imaging techniques.170,171 The exquisite sensitivity of

magnetic resonance to a whole range of biophysical parameters suggests that it will

take center stage in this promising effort.



ACKNOWLEDGMENTS

Andreas Kleinschmidt is funded by the Volkswagen Foundation. We thank Ulf

Ziemann for helpful comments on the manuscript.



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Section II

Neuronal Representations

in the Motor Cortex



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