Tải bản đầy đủ - 0 (trang)
Appendix II: Cytochrome P450 (CYP450) Isoform Data Set Used in Michielan et al. (2009)

Appendix II: Cytochrome P450 (CYP450) Isoform Data Set Used in Michielan et al. (2009)

Tải bản đầy đủ - 0trang

Name



322

859

864

868

2689

3088

3179

3326

3676

3908

5018

5354

5476

5491

5716

5712

5726

6095

6228

6389

6609

6610

6634

6635

8606

8616

8641



No.



1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

19

20

21

22

23

24

25

26

27



0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

1

0

0

0

0

0

0

0

0



CYP1A2

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

1



CYP2C19

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



CYP2C8

0

0

0

0

1

1

1

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



CYP2C9

0

1

0

0

0

0

0

1

1

0

0

0

1

0

1

1

1

1

0

1

1

1

1

1

1

1

0



CYP2D6

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



CYP2E1

1

0

1

0

0

0

0

0

0

1

1

1

0

1

0

0

0

0

0

0

0

0

0

0

0

0

0



CYP3A4

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No



Multilabel

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database



Ref.



156

Appendix II



28

29

30

31

32

33

34

35

36

37

38

39

40

41

42

43

44

45

46

47

48

49

50

51

52

53

54

55



9093

9348

9862

9948

10011

10989

11120

11124

11295

11300

11441

11443

11447

11449

11750

12345

12451

13212

13414

13499

14334

14343

14467

14628

15061

15508

15852

16165



0

0

0

0

1

0

0

0

0

0

0

0

0

0

1

0

0

0

0

0

0

0

0

0

0

0

0

0



0

0

0

0

0

0

0

0

0

0

0

1

1

0

0

0

0

0

0

0

0

0

1

0

0

0

0

0



0

0

0

1

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



0

0

0

0

0

0

1

1

1

1

0

0

0

0

0

0

0

0

0

0

1

1

0

0

0

0

0

0



0

1

1

0

0

0

0

0

0

0

1

0

0

1

0

1

1

1

1

1

0

0

0

1

1

0

0

0



0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

1

1

1



1

0

0

0

0

1

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No



Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

(Continued)



Appendix II

157



Name



16396

16439

16457

16460

16462

16608

16611

16781

17178

17304

17308

18423

19636

19843

19860

20159

20440

21115

21125

21138

21342

21344

21491

22459

22636

23276

23281



No.



56

57

58

59

60

61

62

63

64

65

66

67

68

69

70

71

72

73

74

75

76

77

78

79

80

81

82



0

1

0

0

0

0

0

1

0

0

0

0

0

1

1

0

0

0

0

0

0

0

0

0

1

0

0



CYP1A2

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



CYP2C19

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

1

0

0

0

0

0

0

0

0

0



CYP2C8

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

1

1

0

0

0

0

0

0

0



CYP2C9

0

0

0

0

0

0

0

0

0

1

1

1

0

0

0

1

1

0

0

0

0

0

1

0

0

1

1



CYP2D6

1

0

1

1

1

1

1

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

1

0

0

0



CYP2E1

0

0

0

0

0

0

0

0

1

0

0

0

1

0

0

0

0

0

0

0

1

1

0

0

0

0

0



CYP3A4

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No



Multilabel

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database



Ref.



158

Appendix II



83

84

85

86

87

88

89

90

91

92

93

94

95

96

97

98

99

100

101

102

103

104

105

106

107

108

109

110



23669

23677

24195

25165

25307

25318

25319

25414

25647

26299

27253

27906

27907

27909

29127

29870

29889

30029

30031

30034

30085

30095

30529

30531

31064

31537

31543

31893



1

1

0

0

0

0

0

0

0

1

0

0

0

0

1

0

0

0

0

0

0

0

0

0

0

1

1

0



0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

1

0

0

0

0

0

0

0

0

0

0



0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



0

0

0

1

0

0

0

0

0

0

0

0

0

0

0

1

1

0

0

0

1

0

0

0

0

0

0

0



0

0

1

0

1

0

0

0

1

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

1

0

0

0



0

0

0

0

0

1

1

1

0

0

1

1

1

1

0

0

0

0

1

1

0

1

1

1

0

0

0

1



No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No



Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

(Continued)



Appendix II

159



Name



34120

34454

34455

34457

34458

34475

34579

34690

35597

35600

36005

36731

37213

37474

37599

38395

38398

38402

38404

38407

38416

38528

38680

38744

39279

40334

40472



No.



111

112

113

114

115

116

117

118

119

120

121

122

123

124

125

126

127

128

129

130

131

132

133

134

135

136

137



0

1

1

1

1

0

0

0

0

0

0

0

0

0

0

1

1

0

0

0

1

1

1

0

0

0

0



CYP1A2

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

1

1

1

0

0

0

0

0

0

0



CYP2C19

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



CYP2C8

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



CYP2C9

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

1

0

0

0



CYP2D6

0

0

0

0

0

0

1

1

1

1

0

1

0

0

1

0

0

0

0

0

0

0

0

0

0

0

0



CYP2E1

1

0

0

0

0

1

0

0

0

0

1

0

1

1

0

0

0

0

0

0

0

0

0

0

1

1

1



CYP3A4

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No



Multilabel

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database



Ref.



160

Appendix II



138

139

140

141

142

143

144

145

146

147

148

149

150

151

152

153

154

155

156

157

158

159

160

161

162

163

164



40931

40994

41354

41405

43025

43253

43851

44100

44150

44969

44972

44978

45411

46098

46231

46232

46346

46350

47019

47020

47041

47755

48285

48336

48337

48566

48657



0

0

0

0

0

0

0

0

1

0

0

0

0

1

0

0

1

1

0

1

0

0

0

0

0

1

0



1

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



0

1

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



0

0

0

0

0

1

0

1

0

0

0

1

0

0

0

0

0

0

1

0

1

0

0

1

1

0

0



0

0

0

0

0

0

0

0

0

1

1

0

1

0

0

0

0

0

0

0

0

0

0

0

0

0

0



0

0

1

1

1

0

1

0

0

0

0

0

0

0

1

1

0

0

0

0

0

1

1

0

0

0

1



No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No



Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

(Continued)



Appendix II

161



Name



48894

48895

49260

50413

50588

50826

51201

51488

51727

51728

51830

51831

52799

52801

53365

53367

55175

55955

57002

57004

57197

58162

58164

58173

58176

59883

59887



No.



165

166

167

168

169

170

171

172

173

174

175

176

177

178

179

180

181

182

183

184

185

186

187

188

189

190

191



0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



CYP1A2

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



CYP2C19

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



CYP2C8

0

0

0

1

1

0

0

0

0

0

0

0

0

0

0

1

0

1

0

0

0

0

0

0

0

0

0



CYP2C9

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



CYP2D6

1

1

1

0

0

0

0

0

0

0

0

0

1

1

0

0

0

0

0

0

1

0

0

0

0

1

1



CYP2E1

0

0

0

0

0

1

1

1

1

1

1

1

0

0

1

0

1

0

1

1

0

1

1

1

1

0

0



CYP3A4

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No



Multilabel

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database



Ref.



162

Appendix II



192

193

194

195

196

197

198

199

200

201

202

203

204

205

206

207

208

209

210

211

212

213

214

215

216

217

218

219



59889

60153

60586

60616

60821

60822

60823

60824

61327

61469

61470

61472

61650

61815

61816

62027

62126

62636

62744

63097

63098

63099

63100

63101

63102

63104

63115

63353



0

0

0

0

0

0

0

0

0

1

1

1

1

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



0

0

0

0

0

0

0

1

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



0

0

0

1

1

1

1

0

1

0

0

0

0

1

1

0

0

1

1

0

0

0

0

0

0

0

0

0



1

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

1

1

1

1

1

1

1

0

0



0

1

1

0

0

0

0

0

0

0

0

0

0

0

0

1

1

0

0

0

0

0

0

0

0

0

1

1



No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No



Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

(Continued)



Appendix II

163



Name



63824

63829

64618

64627

64819

64859

64929

65245

66235

66260

66337

66427

66478

67107

67111

67517

67596

68665

68790

68791

69572

69573

69575

69578

69579

69585

69734



No.



220

221

222

223

224

225

226

227

228

229

230

231

232

233

234

235

236

237

238

239

240

241

242

243

244

245

246



0

0

0

1

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



CYP1A2

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



CYP2C19

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

1

1

0

0

0

0

0

0

0



CYP2C8

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

1

1

1

1

1

1

0



CYP2C9

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



CYP2D6

0

0

0

0

0

1

0

0

0

0

0

1

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



CYP2E1

1

1

1

0

1

0

1

1

1

1

1

0

1

1

1

1

1

1

0

0

0

0

0

0

0

0

1



CYP3A4

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No



Multilabel

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database



Ref.



164

Appendix II



247

248

249

250

251

252

253

254

255

256

257

258

259

260

261

262

263

264

265

266

267

268

269

270

271

272

273

274



69807

70401

70678

70714

71062

71072

71098

71099

71410

72142

72588

72922

73006

73066

73076

73184

73186

73201

73211

72212

73334

Aceclofenac

Acecnocoumarol

Acetaminophen

Alfentanil

Alfuzosin

Almotriptan

Alpidem



0

0

0

0

0

0

1

1

0

0

0

0

1

0

0

0

0

0

0

0

0

0

0

1

0

0

0

0



0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



1

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



0

0

0

0

0

0

0

0

0

0

1

0

0

0

0

0

0

0

0

0

0

1

1

0

0

0

0

0



0

1

0

1

1

1

0

0

0

0

0

1

0

0

1

0

0

0

0

0

0

0

0

0

0

0

0

0



0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



0

0

1

0

0

0

0

0

1

1

0

0

0

1

0

1

1

1

1

1

1

0

0

0

1

1

1

1



No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

Yes

No

No

No

No

No



Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Metabolite Database

Bonnabry (2001)

Bonnabry (2001)

Block (2008)

Block (2008)

Block (2008)

Block (2008)

Manga (2005)

(Continued)



Appendix II

165



275

276

277

278

279

280

281

282

283

284

285

286

287

288

289

290

291

292

293

294

295

296

297

298

299

300

301



No.



Alprazolam

Alprenolol

Amiflamine

Amiodarone

Amitriptyline

Amlodipine

Amphetamine

Amprenavir

Aprepitant

Aripiprazole

Astemizole

Atazanavir

Atomexetine

Atorvastatin

Azatadine

Beclomethasone

Benzphetamine

Bepridil

Bexarotene

Bisoprolol

Bromocriptine

Budesonide

Bufuralol

Buspirone

Busulfan

Caffeine

Carbamazepine



Name



0

0

0

0

1

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

1

0



CYP1A2

0

0

0

0

1

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



CYP2C19

0

0

0

1

0

0

0

0

0

0

0

0

0

0

0

0

1

0

0

0

0

0

0

0

0

0

1



CYP2C8

0

0

0

0

1

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



CYP2C9

0

1

1

0

1

0

1

0

0

1

0

0

1

0

0

0

0

0

1

0

0

0

1

0

0

0

0



CYP2D6

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0



CYP2E1

1

0

0

1

1

1

0

1

1

1

1

1

0

1

1

1

0

1

0

1

1

1

0

1

1

1

1



CYP3A4

No

No

No

Yes

Yes

No

No

No

No

Yes

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

Yes

Yes



Multilabel

Block (2008)

Drug Interaction

Manga (2005)

Block (2008)

Block (2008)

Block (2008)

Block (2008)

Block (2008)

Block (2008)

Drug Interaction

Block (2008)

Block (2008)

Block (2008)

Block (2008)

Block (2008)

Block (2008)

Block (2008)

Block (2008)

Block (2008)

Block (2008)

Block (2008)

Block (2008)

Manga (2005)

Block (2008)

Block (2008)

Block (2008)

Block (2008)



Ref.



166

Appendix II



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Appendix II: Cytochrome P450 (CYP450) Isoform Data Set Used in Michielan et al. (2009)

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